Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF-κB and PPAR-γ pathways.
Identifieur interne : 000004 ( Main/Exploration ); précédent : 000003; suivant : 000005Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF-κB and PPAR-γ pathways.
Auteurs : Maged E. Mohamed [Égypte] ; Sahar A. Elsayed [Égypte] ; Hafez R. Madkor [Égypte] ; Heba M Saad Eldien [Égypte] ; Omar M. Mohafez [Égypte]Source :
- Intestinal research [ 1598-9100 ] ; 2020.
Abstract
Background/Aims
Ulcerative colitis (UC) is a chronic inflammatory disorder with indefinite etiology; however, environmental, genetic, immune factors and microbial agents could be implicated in its pathogenesis. UC treatment is lifelong, therefore; the potential side effects and cost of the therapy are significant. Yarrow is a promising medicinal plant with the ability to treat many disorders, owing to its bioactive compounds especially the essential oil. The main aim of this research was to investigate the therapeutic effect of the yarrow oil on colitis including the involved mechanism of action.
Methods
In 21-female C57BL/6 mice were divided into 3 groups; control group, colitis model group, and oil-treated group. Groups 2 and 3 received 5% dextran sulfate sodium (DSS) in drinking water for 9 days, and concomitantly, only group 3 was given 100 mg/kg yarrow oil. Mice were examined for their body weight, stool consistency and bleeding, and the disease activity indexes were calculated.
Results
Oral administration of yarrow oil markedly repressed the severity of UC via the reduction of the inflammatory signs and restoring colon length. The oil was able to down-regulate nuclear factor kappa light chain enhancer of activated B cells (NF-κB), up-regulate peroxisome proliferator-activated receptor gamma (PPAR-γ), and enhance transforming growth factor-β expression. The oil normalized the tumor necrosis factor-α expression, restored the normal serum level of interleukin-10 (IL-10) and reduced the serum level of IL-6.
Conclusions
Yarrow oil mitigated UC symptoms and regulated the inflammatory cytokines secretion via regulation of NF-κB and PPAR-γ pathways in the mice model, however, this recommendation requires further investigations using clinical studies to confirm the use of the oil on humans.
DOI: 10.5217/ir.2020.00021
PubMed: 32819032
Affiliations:
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Mohamed</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacognosy, College of Pharmacy, University of Zagazig, Zagazig, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Pharmacognosy, College of Pharmacy, University of Zagazig, Zagazig</wicri:regionArea><wicri:noRegion>Zagazig</wicri:noRegion></affiliation></author><author><name sortKey="Elsayed, Sahar A" sort="Elsayed, Sahar A" uniqKey="Elsayed S" first="Sahar A" last="Elsayed">Sahar A. Elsayed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Rehabilitation, Faculty of Medicine, Sohag University, Sohag, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Rheumatology and Rehabilitation, Faculty of Medicine, Sohag University, Sohag</wicri:regionArea><wicri:noRegion>Sohag</wicri:noRegion></affiliation></author><author><name sortKey="Madkor, Hafez R" sort="Madkor, Hafez R" uniqKey="Madkor H" first="Hafez R" last="Madkor">Hafez R. Madkor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut</wicri:regionArea><wicri:noRegion>Assiut</wicri:noRegion></affiliation></author><author><name sortKey="Eldien, Heba M Saad" sort="Eldien, Heba M Saad" uniqKey="Eldien H" first="Heba M Saad" last="Eldien">Heba M Saad Eldien</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut</wicri:regionArea><wicri:noRegion>Assiut</wicri:noRegion></affiliation></author><author><name sortKey="Mohafez, Omar M" sort="Mohafez, Omar M" uniqKey="Mohafez O" first="Omar M" last="Mohafez">Omar M. Mohafez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut</wicri:regionArea><wicri:noRegion>Assiut</wicri:noRegion></affiliation></author></analytic><series><title level="j">Intestinal research</title><idno type="ISSN">1598-9100</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background/Aims</b></p><p>Ulcerative colitis (UC) is a chronic inflammatory disorder with indefinite etiology; however, environmental, genetic, immune factors and microbial agents could be implicated in its pathogenesis. UC treatment is lifelong, therefore; the potential side effects and cost of the therapy are significant. Yarrow is a promising medicinal plant with the ability to treat many disorders, owing to its bioactive compounds especially the essential oil. The main aim of this research was to investigate the therapeutic effect of the yarrow oil on colitis including the involved mechanism of action.</p></div><div type="abstract" xml:lang="en"><p><b>Methods</b></p><p>In 21-female C57BL/6 mice were divided into 3 groups; control group, colitis model group, and oil-treated group. Groups 2 and 3 received 5% dextran sulfate sodium (DSS) in drinking water for 9 days, and concomitantly, only group 3 was given 100 mg/kg yarrow oil. Mice were examined for their body weight, stool consistency and bleeding, and the disease activity indexes were calculated.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>Oral administration of yarrow oil markedly repressed the severity of UC via the reduction of the inflammatory signs and restoring colon length. The oil was able to down-regulate nuclear factor kappa light chain enhancer of activated B cells (NF-κB), up-regulate peroxisome proliferator-activated receptor gamma (PPAR-γ), and enhance transforming growth factor-β expression. The oil normalized the tumor necrosis factor-α expression, restored the normal serum level of interleukin-10 (IL-10) and reduced the serum level of IL-6.</p></div><div type="abstract" xml:lang="en"><p><b>Conclusions</b></p><p>Yarrow oil mitigated UC symptoms and regulated the inflammatory cytokines secretion via regulation of NF-κB and PPAR-γ pathways in the mice model, however, this recommendation requires further investigations using clinical studies to confirm the use of the oil on humans.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32819032</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1598-9100</ISSN><JournalIssue CitedMedium="Print"><PubDate><Year>2020</Year><Month>Aug</Month><Day>21</Day></PubDate></JournalIssue><Title>Intestinal research</Title><ISOAbbreviation>Intest Res</ISOAbbreviation></Journal><ArticleTitle>Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF-κB and PPAR-γ pathways.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.5217/ir.2020.00021</ELocationID><Abstract><AbstractText Label="Background/Aims" NlmCategory="UNASSIGNED">Ulcerative colitis (UC) is a chronic inflammatory disorder with indefinite etiology; however, environmental, genetic, immune factors and microbial agents could be implicated in its pathogenesis. UC treatment is lifelong, therefore; the potential side effects and cost of the therapy are significant. Yarrow is a promising medicinal plant with the ability to treat many disorders, owing to its bioactive compounds especially the essential oil. The main aim of this research was to investigate the therapeutic effect of the yarrow oil on colitis including the involved mechanism of action.</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">In 21-female C57BL/6 mice were divided into 3 groups; control group, colitis model group, and oil-treated group. Groups 2 and 3 received 5% dextran sulfate sodium (DSS) in drinking water for 9 days, and concomitantly, only group 3 was given 100 mg/kg yarrow oil. Mice were examined for their body weight, stool consistency and bleeding, and the disease activity indexes were calculated.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Oral administration of yarrow oil markedly repressed the severity of UC via the reduction of the inflammatory signs and restoring colon length. The oil was able to down-regulate nuclear factor kappa light chain enhancer of activated B cells (NF-κB), up-regulate peroxisome proliferator-activated receptor gamma (PPAR-γ), and enhance transforming growth factor-β expression. The oil normalized the tumor necrosis factor-α expression, restored the normal serum level of interleukin-10 (IL-10) and reduced the serum level of IL-6.</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">Yarrow oil mitigated UC symptoms and regulated the inflammatory cytokines secretion via regulation of NF-κB and PPAR-γ pathways in the mice model, however, this recommendation requires further investigations using clinical studies to confirm the use of the oil on humans.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mohamed</LastName><ForeName>Maged E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pharmacognosy, College of Pharmacy, University of Zagazig, Zagazig, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elsayed</LastName><ForeName>Sahar A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Rehabilitation, Faculty of Medicine, Sohag University, Sohag, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Madkor</LastName><ForeName>Hafez R</ForeName><Initials>HR</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eldien</LastName><ForeName>Heba M Saad</ForeName><Initials>HMS</Initials><AffiliationInfo><Affiliation>Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mohafez</LastName><ForeName>Omar M</ForeName><Initials>OM</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>Intest Res</MedlineTA><NlmUniqueID>101572802</NlmUniqueID><ISSNLinking>1598-9100</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Achillea millefolium</Keyword><Keyword MajorTopicYN="N">Asteraceae</Keyword><Keyword MajorTopicYN="N">Inflammatory bowel diseases</Keyword><Keyword MajorTopicYN="N">NF-kappa B</Keyword><Keyword MajorTopicYN="N">PPAR gamma</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>05</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32819032</ArticleId><ArticleId IdType="pii">ir.2020.00021</ArticleId><ArticleId IdType="doi">10.5217/ir.2020.00021</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Égypte</li></country></list><tree><country name="Égypte"><noRegion><name sortKey="Mohamed, Maged E" sort="Mohamed, Maged E" uniqKey="Mohamed M" first="Maged E" last="Mohamed">Maged E. Mohamed</name></noRegion><name sortKey="Eldien, Heba M Saad" sort="Eldien, Heba M Saad" uniqKey="Eldien H" first="Heba M Saad" last="Eldien">Heba M Saad Eldien</name><name sortKey="Elsayed, Sahar A" sort="Elsayed, Sahar A" uniqKey="Elsayed S" first="Sahar A" last="Elsayed">Sahar A. Elsayed</name><name sortKey="Madkor, Hafez R" sort="Madkor, Hafez R" uniqKey="Madkor H" first="Hafez R" last="Madkor">Hafez R. Madkor</name><name sortKey="Mohafez, Omar M" sort="Mohafez, Omar M" uniqKey="Mohafez O" first="Omar M" last="Mohafez">Omar M. Mohafez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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